![]() ![]() The vaccine does not contain the smallpox virus and cannot give you smallpox. Prevention: Smallpox can be prevented by vaccination with smallpox vaccine.Transmission can also occur via contact with material from the smallpox pustules or crusted scabs, or through materials such as bedding or clothing that has been in contact with the pustules or scabs. Transmission: Smallpox can be transmitted person-to-person via inhalation of virus-containing airborne droplets of saliva from an infected person.While there is no known immediate, direct threat of a biological attack using smallpox (i.e., an intentional release of Variola virus), concerns over the possible use of Variola virus in a biological attack have led to increased preparedness efforts.The last outbreak of smallpox in the United States occurred in 1949. Smallpox was declared eradicated in 1980 by the World Health Organization, with no known cases of naturally occurring smallpox having occurred since 1977.Variola virus is the causative agent of smallpox.The IV formulation is an option for those who are unable to swallow the oral capsule. The oral formulation of the drug was originally approved in 2018. May 18, 2022: FDA approved an intravenous (IV) formulation (PDF, 565 KB) of TPOXX (tecovirimat) to treat smallpox.To determine the expiration date for product received from the SNS, find the lot number on the product label and refer to this table to identify the corresponding expiration date. TPOXX supplied by the Strategic National Stockpile (SNS) does not have an expiration date printed on its label. February 22, 2023: On February 3, 2023, FDA approved a shelf-life extension of TPOXX (tecovirimat) Injection, 200 mg, from 24 months to 42 months for some lots of TPOXX injection. ![]() Information about FDA's response to mpox is available at: FDA Mpox Response. ![]()
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